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Are there any issues with Glucose quantification?

17 May 2016 admin Comments Off on Are there any issues with Glucose quantification? FAQ - Profiling Spectra

There are some issues while measuring Glucose concentrations in a mixture.

Glucose exists in solution as 2 anomers (alpha, beta) that are capable of interconverting in solution. In fact all cyclic structures of monosaccharides exhibit anomeric versions. The equilibrium between the 2 forms and therefore their relative proportion is dictated by pH since the interconversion is catalyzed by acid or base.

The signature of all the sugars in the Chenomx library reflect the proportion that exists at neutral
pH and is therefore a weighted average.

We do not have separate entries for the pure forms.


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